【佳學(xué)基因檢測(cè)】癌癥基因治療中的腺相關(guān)病毒 (AAV) 載體

腫瘤基因檢測(cè)19800元導(dǎo)讀

根據(jù)腫瘤治療的前沿研究知道《J Control Release》在.?2016 Oct 28;240:287-301.發(fā)表了一篇題目為《癌癥基因治療中的腺相關(guān)病毒 (AAV) 載體》腫瘤靶向藥物治療基因檢測(cè)臨床研究文章。該研究由Jorge L Santiago-Ortiz,?David V Schaffer等完成。促進(jìn)了腫瘤的正確治療與個(gè)性化用藥的發(fā)展，進(jìn)一步強(qiáng)調(diào)了基因信息檢測(cè)與分析的重要性。

腫瘤靶向藥物及正確治療臨床研究?jī)?nèi)容關(guān)鍵詞：

細(xì)胞凋亡,結(jié)直腸癌,轉(zhuǎn)移,微小RNA,多藥耐藥,預(yù)后,反復(fù),風(fēng)險(xiǎn)分層,治療目標(biāo)

腫瘤靶向治療基因檢測(cè)臨床應(yīng)用結(jié)果

基于腺相關(guān)病毒 (AAV) 的基因遞送載體已被用于大量基因治療臨床試驗(yàn)，這些試驗(yàn)證明了其強(qiáng)大的安全性和越來(lái)越多的治療單基因疾病的療效。對(duì)于癌癥應(yīng)用，AAV 載體已被用于向臨床前模型以及賊近涉及某些癌癥的臨床試驗(yàn)提供廣泛的轉(zhuǎn)基因庫(kù)。這篇綜述描述了 AAV 載體在癌癥模型中的應(yīng)用，并介紹了載體工程和有效載荷設(shè)計(jì)的發(fā)展，旨在定制 AAV 載體以轉(zhuǎn)導(dǎo)和治療癌細(xì)胞。基因解碼基因檢測(cè)還討論了 AAV 在腫瘤學(xué)中的臨床發(fā)展現(xiàn)狀以及 AAV 在該領(lǐng)域的未來(lái)發(fā)展方向。腺相關(guān)病毒；癌癥;基因傳遞；基因傳遞載體；基因治療。關(guān)鍵詞：EIF2B5；入侵；轉(zhuǎn)移;甲基化；卵巢癌;增殖; lncRNA KCNQ1OT1。

腫瘤發(fā)生與反復(fù)轉(zhuǎn)移國(guó)際數(shù)據(jù)庫(kù)描述：

Gene delivery vectors based on adeno-associated virus (AAV) have been utilized in a large number of gene therapy clinical trials, which have demonstrated their strong safety profile and increasingly their therapeutic efficacy for treating monogenic diseases. For cancer applications, AAV vectors have been harnessed for delivery of an extensive repertoire of transgenes to preclinical models and, more recently, clinical trials involving certain cancers. This review describes the applications of AAV vectors to cancer models and presents developments in vector engineering and payload design aimed at tailoring AAV vectors for transduction and treatment of cancer cells. We also discuss the current status of AAV clinical development in oncology and future directions for AAV in this field.Keywords:?AAV; Adeno-associated virus; Cancer; Gene delivery; Gene delivery vectors; Gene therapy.Keywords:?EIF2B5; Invasion; Metastasis; Methylation; Ovarian cancer; Proliferation; lncRNA KCNQ1OT1.